What class of drug is dexmedetomidine? Precedex is a prescription medicine used as a sedative before and/or during surgical and other procedures. Precedex may be used alone or with other medications. Precedex belongs to a
What class of drug is dexmedetomidine?
Precedex is a prescription medicine used as a sedative before and/or during surgical and other procedures. Precedex may be used alone or with other medications. Precedex belongs to a class of drugs called Sedatives.
What is dexmedetomidine mechanism of action?
Dexmedetomidine is a specific and selective alpha-2 adrenoceptor agonist. By binding to the presynaptic alpha-2 adrenoceptors, it inhibits the release if norepinephrine, therefore, terminate the propagation of pain signals.
Is dexmedetomidine an acid or base?
PRECEDEX is supplied as a clear, colorless, isotonic solution with a pH of 4.5 to 7.0. Each 1 mL of PRECEDEX contains 118 mcg of dexmedetomidine HCl (equivalent to 100 mcg dexmedetomidine base) and 9 mg of sodium chloride in water. The solution is preservative-free and contains no additives or chemical stabilizers.
Is dexmedetomidine controlled?
Precedex (dexmedetomidine hydrochloride) is not a controlled substance.
Why is precedex limited to 24 hours?
The FDA states that if used for >24 hours, dexmedetomidine can cause tolerance and tachyphylaxis. The FDA also states that prolonged exposure can cause a dose-related increase in adverse events such as acute respiratory distress syndrome (ARDS), respiratory failure and agitation.
Is dexmedetomidine a vasodilator?
Actions on the peripheral vasculature depend on the dose of dexmedetomidine: vasodilatation is the result of sympatholysis, which occurs at low doses, and vasoconstriction is the result of direct action on smooth muscles at high doses.
Why is dexmedetomidine used?
Dexmedetomidine is used as an adjuvant for premedication, especially in patients susceptible to preoperative and perioperative stress because of its sedative, anxiolytic, analgesic, sympatholytic, and stable hemodynamic profile.
Is precedex better than propofol?
Conclusions: For ICU patient sedation, dexmedetomidine may offer advantages over propofol in terms of decrease in the length of ICU stay and the risk of delirium. However, transient hypertension may occur when dexmedetomidine is administered with a loading dose or at high infusion rates.
Is precedex a sedative?
Precedex (dexmedetomidine hydrochloride) is an alpha2-adrenergic agonist with sedative properties used for short-term intravenous sedation.
Why is precedex bad?
Adverse effects of dexmedetomidine are mainly restricted to hemodynamic alterations. These include hypertension, bradycardia, and hypotension owing to pre- and postsynaptic α2-receptor activation, which causes vasoconstriction, vasodilatation, and reflex bradycardia (Ebert et al., 2000).
How does precedex make you feel?
The most common adverse reactions to dexmedetomidine are hypertension, hypotension, nausea, bradycardia, hypoxia, and anemia.
Can nurses give precedex?
Registered nurses must complete a moderate sedation inservice and maintain yearly competency. Sedation nurses may then administer midazolam, Fentanyl, Demerol and morphine, under the physician’s direction.