How does vancomycin calculate AUC MIC?

How does vancomycin calculate AUC MIC?

The empiric AUC:MIC ratio for a vancomycin dosing regimen can be predicted in advance by a simple formula: First, divide the total daily dose of vancomycin by the estimated clearance of vancomycin. Then divide this number by the MIC.

How do you calculate the area under a vancomycin curve?

AUC24 is calculated using dose in mg/kg divided by the volume of distribution (Vd) and elimination constant (Ke). Vd is provided using the population median (range) of 0.7 (0.4-1) L/kg.

What is AUC in vancomycin?

The area under the curve (AUC) over 24 hours/minimum inhibitory concentration (MIC) of ≥ 400 best predicts the efficacy of vancomycin, and a trough vancomycin serum concentration between 15 and 20 mg/L has been shown to achieve an AUC/MIC ≥ 400 when the MIC is ≤ 1 in adult patients.

How do you calculate vancomycin ke?

Again, based on population kinetics, it has been determined that we can estimate k e with the equation 0.00083*CrCl + 0.0044.

What are side effects of vancomycin?

Side Effects

• Black, tarry stools.
• blood in the urine or stools.
• continuing ringing or buzzing or other unexplained noise in the ears.
• cough or hoarseness.
• dizziness or lightheadedness.
• feeling of fullness in the ears.
• fever with or without chills.
• general feeling of tiredness or weakness.

When do you hold vancomycin?

When to draw levels: Trough: just before 4th dose of a new regimen (prior to 3rd dose for dosing intervals ≥ 24 hours or changing renal function) – Trough levels should be obtained within 30 minutes before the next scheduled dose.

Why is vancomycin trough high?

Several risk factors have been identified for VIN, which high trough vancomycin level (especially >20 mg/L) or doses (>4 g/day), concomitant use of nephrotoxic agents, prolonged therapy (more than 7 days), and admission to an intensive care unit (especially prolonged stay) are the most common ones (1-4, 14).

What is Red Man’s Syndrome?

Red man syndrome (RMS) is an anaphylactoid reaction caused by the rapid infusion of the glycopeptide antibiotic vancomycin. RMS consists of a pruritic, erythematous rash of the face, neck, and upper torso, which may also involve the extremities, though to a lesser degree.

What is the desired peak for vancomycin?

Target ranges for serum vancomycin concentrations have changed over the years. Early authors suggested peak levels of 30 to 40 mg/l and trough levels of 5 to 10 mg/l, but current recommendations are that peak levels need not be measured and that trough levels of 10 to 15 mg/l or 15 to 20 mg/l,…

What is the trough level of vancomycin?

Vancomycin is a glycopeptide antibiotic, typically used for treatment of MRSA . Traditionally it is recommended to get trough doses to assess efficiency. Typically, we aim for Vancomycin trough levels between 10-20µg/mL (15-20 µg/mL for more severe infections).

What is the clearance of vancomycin?

Clearance Like the aminoglycosides , vancomycin is primarily cleared by glomerular filtration. Correlation of vancomycin clearance to creatinine clearance typically gives values for slope of between 0.5 and 0.8 and y-intercept (non-renal clearance) of up to 15 ml/min.

What is the half life of vancomycin?

The mean elimination half-life of vancomycin from plasma is 4 to 6 hours in subjects with normal renal function. In the first 24 hours, about 75% of an administered dose of vancomycin is excreted in urine by glomerular filtration. Mean plasma clearance is about 0.058 L/kg/h, and mean renal clearance is about 0.048 L/kg/h.