# How does vancomycin calculate AUC MIC?

How does vancomycin calculate AUC MIC? The empiric AUC:MIC ratio for a vancomycin dosing regimen can be predicted in advance by a simple formula: First, divide the total daily dose of vancomycin by the estimated

## How does vancomycin calculate AUC MIC?

The empiric AUC:MIC ratio for a vancomycin dosing regimen can be predicted in advance by a simple formula: First, divide the total daily dose of vancomycin by the estimated clearance of vancomycin. Then divide this number by the MIC.

How do you calculate the area under a vancomycin curve?

AUC24 is calculated using dose in mg/kg divided by the volume of distribution (Vd) and elimination constant (Ke). Vd is provided using the population median (range) of 0.7 (0.4-1) L/kg.

### What is AUC in vancomycin?

The area under the curve (AUC) over 24 hours/minimum inhibitory concentration (MIC) of ≥ 400 best predicts the efficacy of vancomycin, and a trough vancomycin serum concentration between 15 and 20 mg/L has been shown to achieve an AUC/MIC ≥ 400 when the MIC is ≤ 1 in adult patients.

How do you calculate vancomycin ke?

Again, based on population kinetics, it has been determined that we can estimate k e with the equation 0.00083*CrCl + 0.0044.

## What are side effects of vancomycin?

Side Effects

• Black, tarry stools.
• blood in the urine or stools.
• continuing ringing or buzzing or other unexplained noise in the ears.
• cough or hoarseness.
• dizziness or lightheadedness.
• feeling of fullness in the ears.
• fever with or without chills.
• general feeling of tiredness or weakness.

When do you hold vancomycin?

When to draw levels: Trough: just before 4th dose of a new regimen (prior to 3rd dose for dosing intervals ≥ 24 hours or changing renal function) – Trough levels should be obtained within 30 minutes before the next scheduled dose.

### Why is vancomycin trough high?

Several risk factors have been identified for VIN, which high trough vancomycin level (especially >20 mg/L) or doses (>4 g/day), concomitant use of nephrotoxic agents, prolonged therapy (more than 7 days), and admission to an intensive care unit (especially prolonged stay) are the most common ones (1-4, 14).

What is Red Man’s Syndrome?

Red man syndrome (RMS) is an anaphylactoid reaction caused by the rapid infusion of the glycopeptide antibiotic vancomycin. RMS consists of a pruritic, erythematous rash of the face, neck, and upper torso, which may also involve the extremities, though to a lesser degree.

## What is the desired peak for vancomycin?

Target ranges for serum vancomycin concentrations have changed over the years. Early authors suggested peak levels of 30 to 40 mg/l and trough levels of 5 to 10 mg/l, but current recommendations are that peak levels need not be measured and that trough levels of 10 to 15 mg/l or 15 to 20 mg/l,…

What is the trough level of vancomycin?

Vancomycin is a glycopeptide antibiotic, typically used for treatment of MRSA . Traditionally it is recommended to get trough doses to assess efficiency. Typically, we aim for Vancomycin trough levels between 10-20µg/mL (15-20 µg/mL for more severe infections).

### What is the clearance of vancomycin?

Clearance Like the aminoglycosides , vancomycin is primarily cleared by glomerular filtration. Correlation of vancomycin clearance to creatinine clearance typically gives values for slope of between 0.5 and 0.8 and y-intercept (non-renal clearance) of up to 15 ml/min.

What is the half life of vancomycin?

The mean elimination half-life of vancomycin from plasma is 4 to 6 hours in subjects with normal renal function. In the first 24 hours, about 75% of an administered dose of vancomycin is excreted in urine by glomerular filtration. Mean plasma clearance is about 0.058 L/kg/h, and mean renal clearance is about 0.048 L/kg/h.