Which complex compound of platinum is used in chemotherapy? The metal based compounds nowadays are used to treat cancer. Platinum complexes are used in treating cancer patients by its application in cancer chemotherapy treatment. Cisplatin
Which complex compound of platinum is used in chemotherapy?
The metal based compounds nowadays are used to treat cancer. Platinum complexes are used in treating cancer patients by its application in cancer chemotherapy treatment. Cisplatin is the first platinum complex which was observed to have anticancer activity.
Which complex compounds are used in chemotherapy?
Cisplatin and oxaliplatin are the most common and effective complexes in chemotherapy. These complexes are all in square planar d8 configuration.
Which is the example of platinum coordination complexes?
Platinum complexes like cisplatin and carboplatin (Fig. 13.7) exert their antitumor effects by forming DNA adducts and subsequent inhibition of DNA replication and transcription. They have an important role in the treatment of several solid tumors.
Which metal complex is used in cancer treatment?
Platinum drugs, such as cisplatin, carboplatin and oxaliplatin, are the mainstay of the metal-based compounds in the treatment of cancer, but the delay in the therapeutic accomplishment of other metal-based compounds hampered the progress of research in this field.
What are side effects of platinum complex?
Other common side effects include anaphylaxis, cytopenias (including leukopenia and neutropenia, thrombocytopenia, and anaemia), hepatotoxicity, ototoxicity, cardiotoxicity, nausea and vomiting, diarrhea, mucositis, stomatitis, pain, alopecia, anorexia, cachexia, and asthenia.
Is platinum used in chemotherapy?
Platinum compounds, including cisplatin, carboplatin, and oxaliplatin, are some of the most commonly used and active chemotherapy drugs utilized by oncologists today.
What is the strongest ligand?
According to this series $CO$ is the strongest ligand among the following because carbon is donor in this, it has double bond $(C = O)$ and is positively charged. Note: The strength of any ligand is determined by the amount of crystal field energy (CFT).
Does chemo have heavy metals?
Heavy metals. Two chemotherapy agents contain the heavy metal platinum. These agents cause crosslinking in DNA, making it impossible for the dividing cell to duplicate its DNA, leading eventually to cell death. Carboplatin and cisplatin are the heavy metal chemotherapy drugs.
Which base of DNA binds to CIS Platin in cancer treatment?
Cisplatin binds to the N7 reactive center on purine residues and as such can cause deoxyribonucleic acid (DNA) damage in cancer cells, blocking cell division and resulting in apoptotic cell death. The 1,2-intrastrand cross-links of purine bases with cisplatin are the most notable among the changes in DNA.
What is platinum chemo?
Platinum-based antineoplastic drugs (informally called platins) are chemotherapeutic agents used to treat cancer. They are coordination complexes of platinum. These drugs are used to treat almost half of people receiving chemotherapy for cancer.
Is there platinum in chemotherapy?
Platinum-based agents are important drugs or drug candidates for cancer chemotherapy. Traditional platinum drugs including the globally approved cisplatin, carboplatin and oxaliplatin are neutral platinum (II) complexes with two amine ligands and two additional ligands that can be aquated for further binding with DNA.