What does it mean when GGT and ALT are high? High levels of liver enzymes GGT, ALT and AST are predictive of disease and all-cause mortality and can reflect liver injury, fatty liver and/or oxidative
What does it mean when GGT and ALT are high?
High levels of liver enzymes GGT, ALT and AST are predictive of disease and all-cause mortality and can reflect liver injury, fatty liver and/or oxidative stress.
Can GGT levels fluctuate?
GGT activity can fluctuate between 10 and 15% from day to day. GGT activity decreases immediately after eating. GGT activity is 25 to 50% higher in obese individuals.
When should I be concerned about GGT?
In adults, GGT levels in the range of 0 to 30 IU/L are normal. Anything above 30 IU/L could be a sign that your liver isn’t working the way it should. Several types of liver disease can cause a rise in GGT, including: Viral hepatitis.
What happens if GGT is low?
Usually, the higher the level of GGT, the greater the level of damage to the liver. If your results show you have low or normal levels of GGT, it means you probably don’t have liver disease. Your results may also be compared with the results of an ALP test. ALP tests help diagnose bone disorders.
How are GGT results interpreted in liver panel?
Results of the GGT are interpreted along with ALP results and with other tests results that may have been performed at the same time, such as a liver panel. An elevated ALP with a high GGT level helps rule out bone disease as the cause of the increased ALP level.
When to use gamma glutamyl transferase ( GGT ) test?
The gamma-glutamyl transferase (GGT) test may be used to determine the cause of elevated alkaline phosphatase (ALP). Both ALP and GGT are elevated in disease of the bile ducts and in some liver diseases, but only ALP will be elevated in bone disease.
When does gamma glutamyl transferase rise in viral hepatitis?
GGT typically rises during the first week of viral hepatitis, peaks at 5 times the upper limit of normal during the second or third week, and remains elevated up to six weeks.
Where does GGT come from in the body?
Even though renal tissue has the highest level of GGT, the enzyme present in the serum appears to originate primarily from the hepatobiliary system, and GGT activity is elevated in any and all forms of liver disease. It is highest in cases of intra- or posthepatic biliary obstruction, reaching levels some 5 to 30 times normal.