Can zonisamide cause weight loss? The zonisamide group (n = 19) had a mean weight loss of 9.2 kg (1.7 kg) (9.4% loss) at week 32 compared with 1.5 kg (0.7 kg) (1.8% loss) for
Can zonisamide cause weight loss?
The zonisamide group (n = 19) had a mean weight loss of 9.2 kg (1.7 kg) (9.4% loss) at week 32 compared with 1.5 kg (0.7 kg) (1.8% loss) for the placebo group (n = 17) (t = 4.0; P<. 001). Zonisamide was tolerated well, with few adverse effects.
How much weight can you lose on Zonegran?
But those getting Zonegran lost an average of 13 pounds. Side effects — mostly fatigue — were mild. However, Zonegran is known to cause dizziness, impaired thinking, and sleepiness in epilepsy patients. It’s also been linked — rarely — to kidney stones.
How effective is zonisamide for weight loss?
A total of 57% of patients in the zonisamide group vs 10% in the placebo group lost at least 5% of their initial body weight, and 23% of those in the zonisamide group vs 0% in the placebo group lost at least 10% of initial body weight (P=. 05).
Do you gain weight on zonisamide?
Longitudinal assessment indicated that zonisamide was associated with a significantly slower rate of BMI and weight increases compared with placebo (P = . 01). No patients in the zonisamide group experienced significant weight gain, compared with 33% of placebo-treated patients (P = . 009).
Does zonisamide increase metabolism?
Furthermore, zonisamide does not induce its own metabolism and does not induce liver enzymes. However, since zonisamide is metabolized by cytochrome P450, liver enzyme-inducing AEDs will increase zonisamide clearance, and dosage adjustments may be necessary when it is used in combination with certain AEDs.
How long does it take zonisamide to work?
It may take 2 weeks or longer before you feel the full benefit of zonisamide. Continue to take zonisamide even if you feel well. Do not stop taking zonisamide without talking to your doctor, even if you experience side effects such as unusual changes in behavior or mood.
Does zonisamide affect appetite?
How does Zonegran help me lose weight? Zonegran increases monoamines, which suppress the NPY and AgRP neurons in the hypothalamus that stimulate the appetite. Zonegran may also stimulate the pro-opiomelanocortin receptors in the hypothalamus which suppress the appetite.
Does zonisamide suppress appetite?
SIDE EFFECTS: Dizziness, drowsiness, trouble sleeping, lack of coordination, lightheadedness, loss of appetite, diarrhea, and double vision may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.