Which syndrome is caused by tetracycline?

Which syndrome is caused by tetracycline?

Reversible “Fanconi Syndrome” Caused by Degraded Tetracycline.

Can tetracycline cause Fanconi syndrome?

These medications may induce Fanconi syndrome by a variety of different mechanisms. Tetracycline metabolites can cause renal tubular disease with electrolyte imbalance and induce tubular damage within 2 to 8 days after beginning treatment. Reversal of Fanconi syndrome can take up to a year.

Which antibiotic is known to cause a Fanconi like syndrome upon ingestion of expired and degraded?

Well-recognized ingestions include those with outdated tetracycline and aminoglycoside antibiotics, such as gentamicin. Tetracycline toxicity is probably caused by anhydro-4-epitetracycline, a degradation product that is formed when the drug is stored for long periods or kept in a moist environment.

What drugs can cause Fanconi syndrome?

The most frequently implicated drugs are cisplatin, ifosfamide, tenofovir, sodium valproate and aminoglycoside antibiotics, and the new oral iron chelator deferasirox has also recently been associated with FS.

Can tetracycline cause kidney damage?

Another potentially fatal side effect of this antibiotic drug is nephrotoxicity. Acute renal failure associated with tetracycline is not accompanied by oliguria. In the presence of a normal urine volume, increasing azotemia is easily overlooked as a possible cause for rapid deterioration of a patient.

What are the potential side effects or adverse effects of tetracycline?

Nausea, vomiting, diarrhea, loss of appetite, mouth sores, black hairy tongue, sore throat, dizziness, headache, or rectal discomfort may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Is Fanconi an autoimmune disorder?

Additionally, Fanconi Syndrome can develop as a secondary or tertiary effect of certain autoimmune disorders.

Is Fanconi syndrome fatal?

Symptoms and Signs of Fanconi Syndrome In hereditary Fanconi syndrome, the chief clinical features—proximal tubular acidosis, hypophosphatemic rickets, hypokalemia, polyuria, and polydipsia—usually appear in infancy. develops, leading to progressive renal failure that may be fatal before adolescence.

What is Fanconi syndrome?

Fanconi syndrome is a disorder of the kidney tubes in which certain substances normally absorbed into the bloodstream by the kidneys are released into the urine instead.

Is tetracycline bad for your kidneys?

Expired tetracycline can cause a dangerous syndrome resulting in damage to the kidneys.

Which is degradation product of tetracycline caused Fanconi syndrome?

A degradation product of tetracycline such as epi-anhydrotetracycline or anhydrotetracycline was probably the etiologic factor. Frimpter GW, Timpanelli AE, Eisenmenger WJ, Stein HS, Ehrlich LI. Reversible “Fanconi Syndrome” Caused by Degraded Tetracycline.

What are the symptoms of reversible Fanconi syndrome?

Reversible “Fanconi Syndrome” Caused by Degraded Tetracycline. A syndrome of nausea, vomiting, proteinuria, acidosis, glycosuria, and aminoaciduria was observed in three patients. The clinical picture at first resembled that of diabetes mellitus.

How old are the patients who took tetracycline?

The three patients, a 54-yr-old woman, a 13-yr-old girl, and a 13-yr-old boy, were found to have taken deteriorated preparations of tetracycline as treatment, respectively, for maxillary sinusitis, pharyngitis, and respiratory infection. The two children had received tetracycline on previous occasions without bad effects.