Is Tasigna better than Sprycel?

Is Tasigna better than Sprycel?

Giving Tasigna (nilotinib) or Sprycel (dasatinib) to previously untreated CML patients resulted in faster, better responses compared with Gleevec, according to research presented at the American Society of Clinical Oncology annual meeting in early June and published that same month in The New England Journal of …

Which is better imatinib or dasatinib?

Dasatinib is 325 times as potent as imatinib in inhibiting unmutated BCR-ABL kinase in vitro. Since increased inhibition of BCR-ABL kinase correlates with a better clinical response,18 administration of dasatinib as the initial therapy may improve responses in patients with newly diagnosed chronic-phase CML.

What is the best drug for CML?

The standard treatment for chronic phase CML is a tyrosine kinase inhibitor (TKI) like imatinib (Gleevec), nilotinib (Tasigna), dasatinib (Sprycel), or bosutinib (Bosulif). If the first drug stops working or it never really worked well at all, the dose may be increased or another TKI might be tried.

Can Tasigna cure CML?

Proven effective in treating Ph+ CML. For details on clinical results with TASIGNA® (nilotinib) capsules for newly diagnosed patients with Philadelphia chromosome–positive chronic myeloid leukemia in chronic phase (Ph+ CML-CP), see the information below.

Does sprycel affect your immune system?

Sprycel decreases your immune system’s ability to fight infections. If you already have a weakened immune system, taking Sprycel can weaken it further and increase your chances of serious infections. Before starting this drug, tell your doctor if you have any existing problems with your immune system.

How long does CML stay in remission?

Curing CML Is the Ultimate Goal But only about 20%–25% of all CML patients can successfully stop taking the drugs and remain in remission for 3 years or longer, he said, and these patients still must be closely monitored.

How can I reduce the side effects of imatinib?

Imatinib sometimes causes side effects due to the rapid destruction of cancer cells (tumor lysis syndrome). To lower your risk, drink plenty of fluids unless your doctor directs you otherwise. Also, your doctor may prescribe an additional medication.

What are the side effects of dasatinib?

Dasatinib may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

• muscle pain.
• weakness.
• joint pain.
• pain, burning or tingling in the hands or the feet.
• rash.
• skin redness.
• peeling skin.
• swelling, redness, and pain inside the mouth.

What are the long term effects of taking SPRYCEL?

However, some side effects of Sprycel might last longer. Examples of long-term side effects include heart damage from having an abnormal heart rhythm. Or you may have permanent lung damage after experiencing pulmonary hypertension (high blood pressure that occurs in your lungs).

Is SPRYCEL considered chemotherapy?

SPRYCEL is the trade name for the generic chemotherapy drug Dasatinib. In some cases, health care professionals may use the trade name SPRYCEL when referring to the generic drug name Dasatinib. Drug Type: SPRYCEL is a targeted therapy.