What causes Tio?

What causes Tio? TIO is caused by tumors that produce too much of a protein called fibroblast growth factor 23 (FGF23), which controls the balance of phosphorus in the body. What is oncogenic osteomalacia? Oncogenic

What causes Tio?

TIO is caused by tumors that produce too much of a protein called fibroblast growth factor 23 (FGF23), which controls the balance of phosphorus in the body.

What is oncogenic osteomalacia?

Oncogenic osteomalacia — also referred to as tumor-induced osteomalacia (TIO) — is a rare endocrine disorder in which a small bony or soft tissue mesenchymal tumor causes hypophosphatemia via secretion of FGF23 .

What is Tio disease?

Tumor-induced osteomalacia (TIO), also known as oncogenic osteomalacia, is a rare paraneoplastic syndrome characterized by bone pain, muscle weakness and fractures associated with persistent hypophosphatemia due to renal phosphate wasting, inappropriately normal or low 1,25(OH)2D and elevated or inappropriately normal …

What causes hypophosphatemia?

Hypophosphatemia is a serum phosphate concentration < 2.5 mg/dL (0.81 mmol/L). Causes include alcohol use disorder, burns, starvation, and diuretic use. Clinical features include muscle weakness, respiratory failure, and heart failure; seizures and coma can occur. Diagnosis is by serum phosphate concentration.

What is the treatment of osteomalacia?

Treatment for osteomalacia involves providing enough vitamin D and calcium, both required to harden and strengthen bones, and treating disorders that might cause the condition.

Is osteomalacia cancerous?

These tumors most commonly occur in the skin, muscles, or bones of the extremities or in the paranasal sinuses around the head. Most of these tumors are benign, meaning they are not associated with cancer . Oncogenic osteomalacia can occur in children or adults.

Is osteomalacia a rare disease?

In some cases, people with oncogenic osteomalacia may be misdiagnosed as having other disorders such as rheumatic disorders or psychiatric disorders. A misdiagnosis can occur because oncogenic osteomalacia is very rare.

Can osteomalacia be inherited?

This disorder may be acquired or genetic and follow autosomal recessive inheritance. Bone symptoms include rickets in children and softening of bones (osteomalacia) in adults.

How does low phosphate cause osteomalacia?

Osteomalacia is a disease characterized by the softening of the bones caused by impaired bone metabolism primarily due to inadequate levels of available phosphate, calcium, and vitamin D, or because of resorption of calcium. The impairment of bone metabolism causes inadequate bone mineralization.

What are the signs and symptoms of hypophosphatemia?

Some of the tell-tale signs you might have hypophosphatemia, include:

  • Muscle weakness.
  • Softening or weakening of bones.
  • Chronic depletion.
  • Depletion of muscles.
  • Issues with the blood.
  • Altered mental state.
  • Seizures.
  • Numbness.