What is DDAVP nasal spray used for?

What is DDAVP nasal spray used for?

DDAVP Nasal Spray (desmopressin acetate) is a man-made form of a hormone that occurs naturally in the pituitary gland used to treat central cranial diabetes insipidus, increased thirst and urination caused by head surgery or head trauma, hemophilia A, or von Willebrand’s disease Type I.

How does desmopressin promote clotting?

Desmopressin exerts its haemostatic effect by: Inducing synthesis of the von Willebrand factor (VWF) by endothelial cells. Stimulating release of the VWF from its storage sites in endothelial cells. Cleaving the large VWF multimers circulating in plasma into smaller multimers.

Can DDAVP cause blood clots?

It will bind to their platelets and can cause blood clots or a decrease in the number of platelets.

Is DDAVP a blood product?

DDAVP: a useful alternative to blood components in moderate hemophilia A and von Willebrand disease.

What happens when you accidentally swallow nasal spray?

Swallowing less than half a teaspoon of the products can cause serious health problems, such as vomiting, altered heart rate and coma, or death, according to the Food and Drug Administration. Sprays and drops contain the active ingredients tetrahydrozoline, oxymetazoline or naphazoline.

Does desmopressin decreased urine output?

Results: Desmopressin significantly increased urine osmolality, decreased nocturnal total urine volume, reduced the ratio of nocturnal urine volume-to-whole day urine volume and decreased nocturnal voiding frequency.

How long does it take for desmopressin to get out of your system?

After 1 hour, the clotting levels begin to fall off. For most people, desmopressin keeps working for 8-12 hours. A repeat dose may be given at the discretion of your hematologist.

Does desmopressin raise blood pressure?

Infrequently, desmopressin may affect your blood pressure. It may cause an increase or decrease in your blood pressure. A temporary drop in your blood pressure may result in dizziness and a fast heartbeat. Ask your doctor for more details, especially if you have heart problems or high or low blood pressure.

Is nasal spray toxic?

Drug-free saline nasal sprays tend to be safe for people of all ages. Saline sprays can help to loosen and thin any mucus in the nose. They allow easier breathing when congestion arises due to colds or allergies. They contain no medication and have no side effects.

What is the chemical formula for DDAVP nasal spray?

DDAVP®Nasal Spray(desmopressin acetate) is a synthetic analogue of the natural pituitary hormone 8-arginine vasopressin (ADH), an antidiuretic hormone affecting renal water conservation. It is chemically defined as follows: Mol. wt. 1183.34 Empirical formula: C46H64N14O12S2•C2H4O2•3H2O

How much DDAVP should I take for hemostasis?

Use the formulation intended for hemostasis (concentration of 1.5 mg/mL; dose 150 mcg/spray), not the formulation for enuresis (concentration of 0.01%). Weight <50 kg: One spray in one nostril (total dose 150 mcg). Weight ≥50 kg: One spray in each nostril (total dose 300 mcg).

Are there any side effects to taking DDAVP?

Very rare cases of hyponatremia have been reported from world-wide postmarketing experience in patients treated with DDAVP (desmopressin acetate). DDAVP is a potent antidiuretic which, when administered, may lead to water intoxication and/or hyponatremia. Unless properly diagnosed and treated hyponatremia can be fatal.

How much desmopressin acetate is in one ml of DDAVP?

DDAVP Injection 4 mcg/mL contains as active substance, desmopressin acetate, a synthetic analogue of the natural hormone arginine vasopressin. One mL (4 mcg) of DDAVP (desmopressin acetate) solution has an antidiuretic activity of about 16 IU; 1 mcg of DDAVP is equivalent to 4 IU.