What medications are contraindicated with pheochromocytoma?

What medications are contraindicated with pheochromocytoma?

Drugs that increase sympathetic tone such as ketamine, ephedrine, pancuronium, metoclopramide should not be used in patients with pheochromocytoma [22]. Histamine provoking drugs such as morphine and atracurium should also be avoided.

Does doxazosin cause orthostatic hypotension?

WARNINGS Syncope and “First-dose” Effect: Doxazosin, like other alpha-adrenergic blocking agents, can cause marked hypotension, especially in the upright position, with syncope and other postural symptoms such as dizziness.

What happens if you take too much doxazosin?

Taking too much doxazosin can reduce your blood pressure and increase your heart rate. You may feel drowsy, faint and lightheaded.

Can Sildenafil be taken with doxazosin?

Talk to your doctor before using sildenafil together with doxazosin. Combining these medications can lower your blood pressure and increase the risk of dizziness, lightheadedness, fainting, flushing, headache, and nasal congestion.

What foods should be avoided by a patient diagnosed with pheochromocytoma?

Foods high in tyramine, a substance that affects blood pressure, also can make symptoms worse. Tyramine is common in foods that are fermented, aged, pickled, cured, overripe or spoiled….These foods include:

• Some cheeses.
• Some beers and wines.
• Chocolate.
• Dried or smoked meats.

What’s the difference between an alpha-blocker and a beta blocker?

Alpha-blockers work on norepinephrine or noradrenaline, while beta-blockers work on epinephrine or adrenaline. Alpha-blockers affect only blood pressure levels, while beta-blockers affect both the heart and blood pressure. Beta-blockers can cause weight gain, while alpha-blockers do not.

What drugs should not be taken with doxazosin?

Other medications can affect the removal of doxazosin from your body, which may affect how doxazosin works. Examples include azole antifungals (such as itraconazole, ketoconazole), boceprevir, macrolide antibiotics (such as clarithromycin), HIV protease inhibitors (such as lopinavir, ritonavir), among others.

What is the strongest alpha blocker?

Many consider alfuzosin 10 mg to be the superior alpha blocker currently available for treating BPH because it achieves clinically significant improvements in LUTS and has no significant effects on dizziness, asthenia, and ejaculatory dysfunction.

Why is doxazosin taken at night?

Your first dose of doxazosin may make you feel faint, so it is important that you take this dose at bedtime. If you feel dizzy or weary, or if you start sweating, remain lying down until these symptoms have gone. Take doxazosin once each day.

Does doxazosin help erectile dysfunction?

In these patients, the doxazosin association with a dosage of 4 mg allowed for a statistically significant improvement of the erectile deficit: in particular, patients reported quicker erections and a constant erection during the entire intercourse.

Does doxazosin affect erectile dysfunction?

Doxazosin, an alpha1-adrenoceptor antagonist indicated for the treatment of patients with BPH and/or hypertension, is not associated with the occurrence of ED compared with other antihypertensive treatments.

Are there any side effects of taking doxazosin?

A note on priapism risk In rare cases, doxazosin and other alpha-1 blockers may cause priapism, a painful occurrence of persistent and unrelievable penile erection that can lead to impotence if medical attention is not sought as soon as possible.

How is doxazosin substituted in the quinazoline class?

Doxazosin is a member of the class of quinazolines that is quinazoline substituted by an amino group at position 4, methoxy groups at positions 6 and 7 and a piperazin-1-yl group at position 2 which in turn is substituted by a 2,3-dihydro-1,4-benzodioxin-2-ylcarbonyl group at position 4.

What is the clearance of doxazosin in the body?

The clearance of doxazosin is low and ranges from approximately 1-2 ml/min/kg. Hepatic metabolism of doxazosin produces inactive O-demethylated and C-hydroxylated metabolites. Metabolism occurs via O-demethylation of the quinazoline nucleus of doxazosin or via hydroxylation of its benzodioxan portion.

How does doxazosin work on the smooth muscle?

Doxazosin acts by inhibiting the postsynaptic alpha(1)-adrenoceptors on vascular smooth muscle. This inhibits the vasoconstrictor effect of circulating and locally released catecholamines (epinephrine and norepinephrine), resulting in peripheral vasodilation.