What is Paget cancer?

What is Paget cancer?

Paget’s disease of the nipple, also known as Paget’s disease of the breast, is a rare condition associated with breast cancer. It causes eczema-like changes to the skin of the nipple and the area of darker skin surrounding the nipple (areola). It’s usually a sign of breast cancer in the tissue behind the nipple.

Can you survive Paget’s disease?

The prognosis and survival rate for Paget’s disease with a palpable mass are generally about the same as for generic infiltrating ductal carcinoma with a five-year survival rate of about 40% and a 10-year survival rate of about 20%.

Is Paget’s breast cancer curable?

Paget disease can be treated by removing the entire breast (mastectomy) or breast-conserving surgery (BCS) followed by whole-breast radiation therapy. If BCS is done, the entire nipple and areola area also needs to be removed.

Is Paget’s breast cancer fatal?

The prognosis of Paget’s depends on the presence of an invasive cancer and axillary lymph node spread. In Paget’s disease, there is no underlying breast malignancy or lymph node spread and the five-year survival is 92-94% [6,9].

Is Paget’s disease always cancer?

Paget’s disease is a rare form of breast cancer which causes skin changes in the nipple area (bleeding, itching, flaking, and nipple discharge) and accounts for fewer than 3% of all breast cancers. Often, Paget’s is mistaken for eczema or an infection before the correct diagnosis is made.

What is the prognosis for Paget disease?

The 5-year survival rate for a patient with Paget disease and sarcoma is 5-7.5%; however, it may be as high as 50% for those who undergo operative tumor ablation and chemotherapy before metastases occur. The 5-year survival rate for elderly patients with primary nonpagetic sarcoma is 37%.

What triggers Paget’s?

The cause of Paget’s disease of bone is unknown. Scientists suspect a combination of environmental and genetic factors contribute to the disease. Several genes appear to be linked to getting the disease.

What is the life expectancy of someone with Paget’s disease?

In that study, the British General Practice Research Database identified 2465 patients diagnosed with Paget’s disease of bone from 1988 to 1999; retrospective review indicated that 5-yr survival was 67% in patients with Paget’s disease compared with 72% in control patients.

How quickly does Paget’s disease progress?

The initial skin changes of Paget’s disease of the breast may appear relatively benign and many individuals may overlook such symptoms, mistakenly attributing them to an inflammatory skin condition or infection. As a result, diagnosis may be delayed, often up to six months or more.

What are the stages of Paget disease?

Three phases of Paget disease have been described: lytic, mixed lytic and blastic, and sclerotic. In an individual patient, different skeletal lesions may progress at different rates. Thus, at any one time, multiple stages of the disease may be demonstrated in different skeletal regions.

What is the most common age to be diagnosed with Paget’s disease?

Age. People older than 50 are most likely to develop the disease. Sex. Men are more commonly affected than are women.

What kind of skin cancer does Paget’s disease have?

Extramammary Paget’s disease (EMPD) is a rare skin cancer of the genital region in which cancer cells with enlarged nuclei and pale cytoplasm are scattered singly in the affected epidermis. These cancer cells, called Paget cells, contain mucin, which is never found in normal epidermis.

When does Paget disease of the breast occur?

Paget disease of the breast occurs in both women and men, but most cases occur in women. Approximately 1 to 4 percent of all cases of breast cancer also involve Paget disease of the breast. The average age at diagnosis is 57 years, but the disease has been found in adolescents and in people in their late 80s ( 2, 3 ).

Are there any other diseases named after Sir James Paget?

(Several other diseases are named after Sir James Paget, including Paget disease of bone and extramammary Paget disease, which includes Paget disease of the vulva and Paget disease of the penis. These other diseases are not related to Paget disease of the breast.

What kind of protein is found in Paget’s disease?

Paget cells in mucin-positive extramammary Paget’s disease contain MUC5AC core protein (red–brown reaction product). Many Paget cells in mucin-negative extramammary Paget’s disease contain MUC5AC core protein (red–brown reaction product).